Abstract #5284

Longitudinal MRI study of white matter in multiple sclerosis using surrogates measures of myelin and axonal damage.

Gretel Sanabria Sanabria Diaz^1,2,3, Lester Melie-Garcia^1,2,3, Po-Jui Lu ^1,2,3, Muhamed Barakovic^1,2,3, Mario Alberto Ocampo Pineda^1,2,3, Xinjie Chen^1,2,3, Matthias Weigel^1,3,4, Nina Siebenborn^1,2,3, Esther Ruberte Jiménez^1,2,3, Alessandro Cagol^1,2,3, Riccardo Galbusera^1,2,3, Antoine Lutti⁵, Jens Kuhle^2,3, Ludwig Kappos^1,2,3, and Cristina Granziera ^1,2,3

¹Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, ²Department of Neurology, University Hospital Basel, Basel, Switzerland, ³Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, ⁴Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland, ⁵Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

Synopsis

Keywords: Multiple Sclerosis, Multiple SclerosisDamage to the myelin sheath and the neuroaxonal unit are features of multiple sclerosis, as well as reparative processes for both. However, a detailed characterization of the dynamics of those in vivo is challenging. In this longitudinal study, we applied a multi-contrast quantitative MRI approach to disentangle lesion progression in vivo in patients with MS. The microstructural measures were compared between multiple sclerosis groups (55 relapsing-remitting, 24 progressive) and 34 healthy controls. Our results indicate changes in microstructural MRI measures in white matter lesions and normal appearing tissue related to myelin and axonal integrity in RRMS and PMS.

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