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Abstract #5289

Heterogeneous regional growth process and speed in marmoset brain: multi-modal longitudinal MRI study

Akiko Uematsu1, Makoto Fukushima1, Junich Hata2, Ayako Murayama1, Noriyuki Kishi3, Takuya Hayashi1, and Hideyuki Okano3,4
1RIKEN, Hyogo, Japan, 2Tokyo Metropolitan University, Tokyo, Japan, 3RIKEN, Saitama, Japan, 4Keio University School of Medicine, Tokyo, Japan

Synopsis

Keywords: Normal development, Animals“The soul of a child of three is the same at 100” may be also true among all the primates. Here, we delineate the robust value changes of T1w, T2w, and DTI metrics for the first 2 to 3 months after birth in common marmoset brain. Different temporal changes across brain regions were found by Fixel-based analysis, suggesting that different neuronal contributors of age-related structural changes. Integrating multi-modal MRI images provided more detailed insight of tissue property changes especially through development as compared with a single-modal image analysis.

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Keywords