Abstract #5290

Characterisation of pregnancies affected by pre-eclampsia using MRI

Megan Hall^1,2, Kathleen Colford¹, Daniel Cromb¹, Priya Jandu³, Alison Ho^1,2, Anthony Price¹, Lucy Chappell², Mary Rutherford^1,4, Lisa Story^1,2, Pablo Lamata⁴, and Jana Hutter^1,4

¹Centre for the Developing Brain, King's College London, London, United Kingdom, ²Department of Women and Children's Health, King's College London, London, United Kingdom, ³GKT School of Medicine, King's College London, London, United Kingdom, ⁴Centre for Medical Engineering, King's College London, London, United Kingdom

Synopsis

Keywords: Fetal, Fetus, Placenta; hypertension; clinical translationMaternal cardiac, placental and fetal brain anatomical and functional MRI was obtained in 63 pregnancies, including 12 with pre-eclampsia. In pregnancies affected by pre-eclampsia, placental T2* was significantly reduced compared to normal pregnancy. All women with placental histopathological anomalies consistent with pre-eclampsia showed a reduced placental T2*. Fetal brain T2* was significantly lower in women with pre-eclampsia than those without, although brain volume was maintained. In women with pre-eclampsia, reduced fetal brain T2* was associated with middle cerebral artery Doppler abnormalities. Cardiac work was increased in women with pre-eclampsia.

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