Keywords: Tumors, Tumor, optic nerve invasion; quantitative; pediatric; prediction; metastases;Two radiologists with different levels of experience measured the anterior optic nerve to predict postlaminar optic nerve invasion (PLONI) in retinoblastoma. In addition, quantitative measurements were performed using a deep-learning method 3D U-net. The results showed that measurements performed by the radiologists had an AUC of 0.88 for the detection of PLONI, while the preliminary results of the quantitative approach had an AUC of 0.63. Both methods show promising results to predict early-stage PLONI in retinoblastoma patients.
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