Abstract #5293

Glutamate in the visual cortex changes within the migraine cycle in children and adolescents

Lydia Y Cho^1,2,3, Tiffany K Bell^1,2,3, Kate J Godfrey^1,2,3, Andrew D Hershey^4,5, Jonathan Kuziek^2,3,6, Mehak Stokoe^1,2,3, Kayla Millar^1,2,3, Serena L Orr^2,3,6, and Ashley D Harris^1,2,3

¹Department of Radiology, University of Calgary, Calgary, AB, Canada, ²Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ³Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ⁴Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ⁵Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH, United States, ⁶Departments of Pediatrics, Community Health Sciences, and Clinical Neurosciences, University of Calgary, Calgary, AB, Canada

Synopsis

Keywords: Neuro, Spectroscopy, MigraineMigraine is a common neurological disorder in pediatrics, yet the pathophysiology remains unclear. Migraine is characterized by episodic attacks, suggesting a shifting excitation-inhibition imbalance that when tipped, will trigger an attack. We used magnetic resonance spectroscopy to measure glutamate and gamma-aminobutyric acid (GABA) concentrations to examine changes in these brain metabolites across different phases of the migraine attack in children and adolescents. We show fluctuations in glutamate with migraine cycle phases in the visual cortex. There were no observed changes in glutamate nor GABA in the sensorimotor cortex and the thalamus.

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