Abstract #5295

Whole-brain connectivity in patients with Pediatric Cerebellar Ataxia

Silvia Maria Marchese¹, Fulvia Palesi², Mariagrazia Bruzzone³, Anna Nigri³, Chiara Maria Pantaleoni⁴, Claudia AM Gandini Wheeler-Kingshott^2,5,6, Stefano D'Arrigo⁴, Egidio D'Angelo^2,6, and Paolo Cavallari¹

¹Human Physiology Section of the DePT, Università degli Studi, Milano, Italy, ²Department of Brain and Behavioral Science, Università degli Studi, Pavia, Italy, ³Neuroradiology Department, Fondazione IRCCS Istituto Neurologico "C. Besta", Milano, Italy, ⁴Developmental Neurology Department, Fondazione IRCCS Istituto Neurologico "C. Besta", Milano, Italy, ⁵Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, NMR Research Unit, Queen Square MS Centre, London, United Kingdom, ⁶Brain Connectivity Center, IRCCS Mondino Foundation, Pavia, Italy

Synopsis

Keywords: Neuro, Brain Connectivity, AtaxiaFor the first time, brain networks of pediatric cerebellar ataxic patients were characterized in order to explain the different postural motor behavior of subjects suffering from non-progressive and slow-progressive illness. This work revealed volume differences in several cerebellar regions and specific alterations of white matter tracts. This result reinforces the hypothesis of the existence of a compensatory strategy which may involve cortical areas and basal ganglia to compensate for cerebellar deficits.

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