Abstract #5297

Hippocampal subfield alterations and working memory in children with congenital heart disease

Ruth O'Gorman Tuura¹, Melanie Ehrler², Nadja Naef², Alenka Schmid², Felicitas Koch², Fraser Callaghan¹, Oliver Kretschmar³, and Beatrice Latal²

¹University Children's Hospital Zurich, Zurich, Switzerland, ²Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland, ³Cardiology, University Children's Hospital Zurich, Zurich, Switzerland

Synopsis

Keywords: Neuro, SegmentationReduced hippocampal volumes are associated with working memory impairments in children with congenital heart disease (CHD). However, the volumes of individual hippocampal subfields are largely unexplored in the context of different working memory domains in CHD. In 57 children with complex CHD and 82 age-matched control children, the CHD group showed smaller hippocampal subvolumes, particularly for the hippocampal tail, and poorer verbal and spatial working memory scores, which were differentially related to the hippocampal subvolumes. In addition, hippocampal volumes in cyanotic CHD were significantly smaller than in acyanotic CHD, supporting the link between hypoxia, hippocampal damage, and memory impairment.

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