Abstract #5298

Noninvasive MRI Radiomics Features of adenohypophysis in evaluation of HPG axis activation in children.

Dong Liu¹, Wenzhi Lv², Weiyin Vivian Liu³, and Wenzhen Zhu¹

¹Department of Radiology, Tongji Hosptial ofTongji Medical College of Huazhong University of Science and Technology, Wuhan, China, ²Department of Artificial Intelligence,, Julei Technology Company, Wuhan 430000, Hubei, China, Wuhan, China, ³MR Research, GE Healthcare, Beijing 100176, China, Beijing, China

Synopsis

Keywords: Adolescents, Pediatric, hypothalamic-pituitary-gonadal axiswe report for a low-cost and rapid radiomics model based on MRI data in evaluation of hypothalamic-pituitary-gonadal (HPG) axis activation in children. In our study, radiomics model base on CUBE T1WI showed good prediction of HPG axis activation with the AUC of 0.84 in the training set and 0.81 in the test set. The AUC of the radiomics model was higher than that of aPV and aPH in the training set. In results of DCA analysis, radiomics signature showed higher net benefit than aPV and aPH models.The MRI radiomics model may serve as a noninvasive predictor of HPG axis activation.

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