Abstract #5304

Comparing Volumetric to 2D Methods in Assessing Post-treatment Response of Different Pediatric Low-Grade Glioma (pLGG) Tumor Components

Divya Ramakrishnan¹, Marc von Reppert², Sarah C Bruningk³, Fatima Memon¹, Mark Krycia¹, Matthew Sala¹, Ryan Bahar¹, Anahita Fathi Kazerooni⁴, Ali Nabavizadeh⁴, Annette Molinaro⁵, Daphne Haas-Kogan⁶, Theodore Nicolaides⁷, Sabine Mueller⁵, Michael Prados⁵, and Mariam Aboian¹

¹Department of Radiology, Yale School of Medicine, New Haven, CT, United States, ²University of Leipzig, Leipzig, Germany, ³ETH Zurich, Zurich, Switzerland, ⁴Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁵Department of Neurology, Neurosurgery, and Pediatrics, UCSF, San Francisco, CA, United States, ⁶Harvard Medical School, Boston, MA, United States, ⁷NYU Langone Medical Center, New York, NY, United States

Synopsis

Keywords: Neuro, Tumor, VolumetricsAccurate response assessment is critical in pediatric low-grade glioma (pLGG) as there is significant morbidity associated with continued treatment. Current standards for assessment rely on 2D measurements. Given the heterogenous nature of pLGG, volumetric assessment of treatment response may prove more effective. In this study, we compared 2D and volumetric methods of assessing treatment response in patients from the PNOC-002 clinical trial of pLGG. We analyzed the quantitative differences between 2D and volumetric measurements of tumor volume percent change post-treatment. We also compared classification of treatment response based on application of RANO criteria to various pLGG tumor components.

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