Keywords: Diffusion/other diffusion imaging techniques, Microstructure, FEXSY, FEXI, exchange, water transmembrane permeability, cell deathFilter exchange spectroscopy (FEXSY) and imaging (FEXI) were used to measure apparent exchange rate (AXR) in acute myeloid leukemia cells undergoing apoptosis, necroptosis, or necrosis. Sensitivity of AXR to membrane permeabilization in vitro, while ADC was stable, were confirmed by Annexin V/PI staining and by scanning electron microscopy of microstructural leaks upon necrosis. AXR of murine EL4 lymphoma showed negative and positive correlation with ADC and malate/fumarate ratio, respectively. Tumor H&E histological analyses show clusters of diffuse necrosis in the solid tumor region, which likely contribute to high AXR and MFR variation while ADC is still low.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords