Abstract #5315

Quantitative relaxometry assessment of brain microstructural abnormality of preschool children with autism spectrum disorder by Synthetic MRI

Shuangyu Li¹, Xin Zhao¹, Lin Lu¹, Jinxia Guo², Qingna Xing¹, Yongbing Sun³, Desheng Xuan¹, and Xiaoan Zhang¹

¹Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²GE Healthcare, MR Research China, Beijing, China, ³Zhengzhou University People’s Hospital, Zhengzhou, China

Synopsis

Keywords: Neuro, NeuroscienceQuantitative T1/T2 relaxometry can be simultaneously generated from Synthetic MRI (SyMRI) in one single scanning and short time. This study aims to use SyMRI to evaluate the brain structural changes in preschool children with autism spectrum disorder (ASD), and the correlation between T1/T2 and ASD scores, as well as the diagnostic efficacy. We found that Synthetic T1 and T2 could be helpful for brain abnormity assessing, pathophysiological mechanism understanding and diagnosis of ASD.

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