Abstract #5316

Altered cerebellar lobular volumes correlate with neurodevelopment and cognitive scores in children with ASD and ASD-siblings at an early age

Manoj Kumar¹, Chandrakanta Hiremath², Eshita Bansal², Sunil Kumar Khokhar², Kommu Johnvijay Sagar³, Swetha Narayanan⁴, Akhila S. Girimaji⁵, BK Yamini⁵, Rose Dawn Bharath², Jitender Saini², and M. Thamos Kishore⁴

¹Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India, ²Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India, ³Child and Adolescents Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India, ⁴Clinical Psychology, National Institute of Mental Health and Neurosciences, Bengaluru, India, ⁵Speech pathology and Audiology, National Institute of Mental Health and Neurosciences, Bengaluru, India

Synopsis

Keywords: Neonatal, Neonatal, Neurodevelopmental disorders, ASDNeuroimaging methods comparing individuals with ASD and healthy-controls posited a distinction in various cerebellar regions; including arrested growth of posterior vermis and reduced gray matter in right Crus I, and lobule VIII and IX. Younger cohorts of ASD, ASD-siblings, and healthy-children demonstrates volumetric differences in cerebellar lobules and look for correlation with neurodevelopmental measures. Multiple cerebellar lobules demonstrate abnormal volumes in ASD compared to ASD-sibling and healthy controls, including Vermis, dentate, and lobule I-V. Lobular volumes were also significantly correlates with social quotient, language, and cognition measures in ASD.

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