Abstract #5317

Characterising the lifespan trajectory of six essential neurometabolites in a cohort of 100 participants.

Alice Thomson^1,2, Duanghathai Pasanta¹, Hannah Hwa¹, Tomoki Arichi^2,3, Richard Edden⁴, Xiaoqian Chai⁵, and Nicolaas Puts^1,2

¹Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, London, United Kingdom, ²MRC Centre for Developmental Neurobiology, King's College London, London, United Kingdom, ³Centre for the Developing Brain, King's College London, London, United Kingdom, ⁴Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada

Synopsis

Keywords: Normal development, Spectroscopy, GABA, Normative, metabolites, childhood, adolescence, adult

We characterised the normative lifespan trajectories of brain neurometabolites, as measured by ¹H-Magnetic Resonance spectroscopy (¹H-MRS) from the posterior parietal cortex across 100 individuals (aged 5-40 yrs). Glutamate + glutamine (Glx), N-acetylaspartate (NAA), gamma-aminobutyric acid (GABA+) and glutathione (GSH) showed non-linear trajectories, decreasing steeply in childhood/adolescence before a gradual, significant, decline across early adulthood. Results suggest age associated changes in brain composition may contribute to the observed trajectories. Importantly, a non-linear regression modelling approach was found to be more appropriate for neurometabolite trajectories than a linear regression model and should be considered in future to prevent simplification of data trends.

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