Keywords: Blood vessels, Pediatric, Cerebrovascular, reactivity, CVR, moyamoyaWe compared the reliability of BOLD CVR (cerebrovascular reactivity) between two regression approaches – etpCO2 signal and average cerebellar signal – in pediatric moyamoya patients. We estimated CVR using a lagged optimized GLM model, conducted cortical parcellation, and compared left-right hemispheric CVR differences to clinical and imaging reports. We found that etpCO2 had poorer fits during regression compared to the cerebellar approach (p<0.0001) and incorrectly identified disease laterality in 2/8 patients. These effects were strongly observed in subjects with poor breath-hold task compliance, indicating that the cerebellar approach is more reliable for studies of young pediatric moyamoya patients.
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