Abstract #5325

Feasibility of a multimodal MR Imaging and Spectroscopy approach in understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Raminder Kaur^1,2, Kashish Mehta^1,2, Alexander Ciok^1,2, Brian Greeley¹, Kati Debelic³, Hilary Robertson³, Todd Nelson^1,2, Melody Tsai⁴, Lan Xin Zhang^1,5, Margit Glashutter^1,2, Travis Boulter⁴, Luis Nacul*^4,6, and Xiaowei Song*^1,2

¹Clinical Research, Fraser Health Authority, Surrey, BC, Canada, ²Department of Biomedical Physiology Kinesiology, Simon Fraser University, Burnaby, BC, Canada, ³Patient partner in Research, Community member, Vancouver, BC, Canada, ⁴BC Women's Hospital & Health Centre, Vancouver, BC, Canada, ⁵Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁶University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Head & Neck/ENT, MultimodalThis first multimodal MRI/MRS study aiming to investigate whether an extensive multimodal neuroimaging approach is feasible for patients with ME/CFS. The study compared female ME/CFS participants to aged matched female healthy controls. The study showed successful completion of the entire protocol that included: anatomical imaging; functional magnetic resonance imaging (fMRI) along with a working memory task; single-voxel magnetic resonance spectroscopy (MRS) to quantify metabolites at three locations (ACC, BS, and l-DLPC); and a hand-grip strength to observe whether fatigue is induced due to the scanning protocol. It also suggested a minimum impact of the MRI session on grip strength.

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