Abstract #5326
Quantitative susceptibility mapping of hippocampal iron relates to pattern separation and completion in older adults at risk for Alzheimer's
Jing Zhou1, Alfie Wearn1, Julia Huck2, Giulia Baracchini1, Jennifer Tremblay-Mercier3, Judes Poirier3,4, Sylvia Villeneuve3,4,5,6, Christine Tardif 4,6, Ana Daugherty7, Claudine Gauthier2,8, Gary R Turner9, and R Nathan Spreng6,10,11,12
1Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 2PERFORM Centre, Concordia University, Montreal, QC, Canada, 3StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montreal, QC, Canada, 4McGill University, Montreal, QC, Canada, 5McGill Centre for Integrative Neuroscience, McGill University, Montreal, QC, Canada, 6McConnell Brain Imaging Center, McGill University, Montreal, QC, Canada, 7Department of Psychology and Institute of Gerontology, Wayne State University, Detroit, MI, United States, 8Physics Department, Concordia University, Montreal, QC, Canada, 9Department of Psychology, York University, Toronto, ON, Canada, 10Department of Neurology and Neurosurgery, Montréal Neurological Institute, Montreal, QC, Canada, 11Douglas Mental Health University Institute, Montreal, QC, Canada, 12Departments of Psychiatry and Psychology, McGill University, Montreal, QC, Canada
Synopsis
Keywords: Alzheimer's Disease, Quantitative Susceptibility mapping, Human MemoryQuantitative susceptibility mapping (QSM) was used to evaluate hippocampal iron in a cohort of healthy older individuals at elevated risk for Alzheimer’s disease (AD), and related to pattern separation and pattern completion memory performance. Our results demonstrated that elevated brain iron content in the hippocampus is strongly associated with lower performance on behavioral tests specific to memory function, ie lower pattern separation scores and higher pattern completion scores. Our findings suggest that hippocampal iron deposition may be a pathological mechanism resulting in poorer mnemonic discrimination in later life
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