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Abstract #5328

Enhancement of Pulse Simulation in Quantifying Procedure of Very Slow CSF Flow Measurement with Shunt-FENSI

Mingxiao Zhang1,2, Suguna Pappu3,4, William C. Olivero3,4, Jason M. Huston3,5, and Bradley P. Sutton1,2,3
1Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, IL, United States, 2Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Neurosurgery, Carle Foundation Hospital, Urbana, IL, United States, 5Department of Radiology, Carle Foundation Hospital, Urbana, IL, United States

Synopsis

Keywords: Neurofluids, Brain, Flow, Hydrocephalus, CSF, QuantitativeVentriculoperitoneal shunts drain excessive cerebrospinal fluid (CSF) for hydrocephalus patients, but shunts placed shortly after birth 50% fail within 2 years. Since rapid MRI is becoming the standard for imaging possible shunt malfunction, an MRI technique that assesses shunt flow at the same imaging setting, would be beneficial. Previously, the non-invasive quantitative method, Shunt Flow Enhancement of Signal Intensity (Shunt-FENSI), was proposed for diagnosing possible shunt failure. An improvement in its flow data simulation and quantification is included, more accurately reflecting the RF pulse application in the pulse sequence. Improvements are demonstrated on phantom, extraventricular drain (EVD), and shunt patients.

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Keywords