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Abstract #5329

SNR and Dose Considerations for Hyperpolarized 129Xe Magnetic Resonance Spectroscopy

Haoran Dai1, Elianna Bier2, David Mummy3, Alexander Church3, Aryil Bechtel3, Anna Costelle1, and Bastiaan Driehuys1,2,3
1Medical Physics Graduate Program, Duke University, Durham, NC, United States, 2Department of Biomedical Engineering, Duke University, Durham, NC, United States, 3Department of Radiology, Duke University, Durham, NC, United States

Synopsis

Keywords: Hyperpolarized MR (Gas), SpectroscopyHyperpolarized 129Xe MR spectroscopy is a powerful tool for evaluating gas exchange, blood oxygenation and hemodynamics. However, there is no established method for determining the HP 129Xe dose equivalent required to achieve scans of sufficient quality for analysis. Here, we establish a robust approach to calculate the 129Xe MRS SNR and assess its relationship to the 129Xe dose equivalent.

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