Abstract #5331

A highly automated experimental setup to perform PHIP via proton exchange with high pressure and high reproducibility at various magnetic fields

Jule Kuhn¹, Kolja Them¹, and Jan-Bernd Hövener¹

¹Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Medical Center Schleswig - Holstein, Kiel University, Kiel, Germany

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Contrast AgentThe PHIP-X methodology is a novel approach to produce contrast agents for metabolic MRI by hyperpolarization and combines the high polarization resulting from pH₂ addition with the versatility of proton exchange. However, the polarization yield and reproducibility have to be improved. The proposed setup provides reproducible and well controlled experimental conditions for PHIP-X, including a pH₂ pressure of up to 100 bar and a magnetic field of up to 95 mT. Using this setup allowed to reach high ¹H polarizations of the transfer agent and to transfer the polarization to ¹³C in the target molecule glucose successfully.

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