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Abstract #5332

Reproducibility of 13C labeling of glutamate and glutamine in human brain using selPOCE MRS at 7T upon [U-13C]-labeled glucose infusion

Narjes Ahmadian1,2, Sarah M Jacobs1, Mark Gosselink1, Wybe JM van der Kemp1, Hans Hoogduin1, Anastasia Coppoli3, Graeme F Mason3, Robin A de Graaf3, Helia Norouzizadeh4, Chantal Mahon5, Sjoerd van Marle6, Pieter van Eijsden2, Dirk Cerneus6, Corin O Miller5, Inge De Lepeleire4, Anthony S Basile5, Dennis W Klomp1, Jeanine J Prompers1, and Evita C Wiegers1
1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands, 3Yale University School of Medicine, New Haven, CT, United States, 4MSD (Europe) Inc, Brussel, Belgium, 5Merck & Co. Inc, Kenilworth, NJ, United States, 6ICON plc, Groningen, Netherlands

Synopsis

Keywords: Non-Proton, Metabolism, 13CThe aim of this study is to assess the reproducibility of a selective proton-observed, carbon-edited (selPOCE) MRS sequences for the detection of glutamate/glutamine cycling at 7T in healthy participants. Participants were scanned twice while undergoing [U-13C] glucose infusion. The time course of Glu C45 and Gln C45 labeling were similar for test-retest measurements. This supports the application in future studies on measuring neuroenergetics and neurotransmitter cycling.

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