Abstract #5334

The effect of elevated serum lactate on measures of apparent cerebral metabolism and perfusion in the anesthetised rodent brain.

Jordan McGing¹, Daniel Radford-Smith², Richard Healicon³, Catriona H. E. Rooney³, Ayaka Shinozaki¹, Surrin Deen³, Tricia Seow³, Vicky Ball³, Fulvio Zaccagna ³, Sean Smart⁴, Daniel Anthony², Damian J Tyler^1,3, and James T Grist^1,3,5,6

¹Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, ²Department of Pharmacology, University of Oxford, Oxford, United Kingdom, ³Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, ⁴Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ⁵Department of Radiology, University of Oxford, Oxford, United Kingdom, ⁶Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom

Synopsis

Keywords: Neurodegeneration, Hyperpolarized MR (Non-Gas)It is unclear how serum lactate perturbations influence the quantification of cerebral blood flow (CBF) and metabolism using proton perfusion imaging and hyperpolarized ¹³C MRI. Low dosage L-lactate injection increased CBF and cerebral LDH flux, whilst high dosage lactate decreased CBF and maintained the increased LDH flux, relative to saline administration. Lactate administration did not alter apparent oxidative metabolism. This suggests the efficacy of probing oxidative metabolism with ¹³C MRI when alterations in serum lactate are present (e.g. in pathology). But highlights the requirement for serum lactate measurement prior to interpretation of ¹³C metabolic data.

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