Meeting Banner
Abstract #5335

7T MRI and CSF correlates of brain iron accumulation, neurodegeneration and neuroinflammation in Huntington's Disease: Study Protocol

Nadine van de Zande1, Marjolein Bulk2, Chloé Najac2, Louise van der Weerd2,3, Jeroen de Bresser2, Jan Lewerenz4, Itamar Ronen5, and Susanne de Bot1
1Neurology, Leiden University Medical Centre, Leiden, Netherlands, 2Radiology, Leiden University Medical Centre, Leiden, Netherlands, 3Human Genetics, Leiden University Medical Centre, Leiden, Netherlands, 4Neurology, University of Ulm, Ulm, Germany, 5Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom

Synopsis

Keywords: Neuroinflammation, Quantitative Susceptibility mapping, Huntington's DiseaseHD is a rare, autosomal dominant inherited, progressive, neurodegenerative disorder. Strong evidence suggests a significant role for iron accumulation and neuroinflammation in HD. Previous studies already showed iron accumulation in the brain of patients with HD, but no other study linked these results with well-accepted biofluid biomarkers for neuroinflammation, or with neuroimaging methods to assess neuroinflammation. This study will provide an important basis for the evaluation of brain iron levels and neuroinflammation metabolites as imaging biomarkers for disease state and progression in HD and their relationship with the salient pathophysiological mechanisms of the disease.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords