Abstract #5342

Exploring the Frontal Aslant Tract in Tourette syndrome: a connectivity study

Domenico Aquino¹, Daniela Eldahaby², Emanuele La Corte³, Vincenzo Levi³, Elena Greco², Greta De Michelis¹, Riccardo Pascuzzo¹, Alessandro Gans², Malte Ottenhausen⁴, Luigi Michele Romito⁵, Maria Grazia Bruzzone¹, and Graziano Serrao²

¹Neuroradiology Department, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Neurologico Carlo Besta, Milan, Italy, ²Department of Health Sciences, Università degli Studi di Milano, Milan, Italy, ³Neurosurgery Department, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Neurologico Carlo Besta, Milan, Italy, ⁴Department of Neurological Surgery, University Medical Center Mainz, Mainz, Germany, ⁵Parkinson's Disease and Movement Disorders Unit, Department of Clinical Neurosciences, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Neurologico Carlo Besta, Milan, Italy

Synopsis

Keywords: White Matter, Tractography & Fibre ModellingThis study investigates for the first time microstructural alteration of the Frontal Aslant Tract (FAT) in nine subjects with TS compared to twelve healthy subjects. FAT was reconstructed trough Spherical Deconvolution (SD) and parameters derived from Diffusion Tensor Imaging (DTI) and Neuritis Orientation Dispersion and Density Imaging (NODDI) were extracted. We observed a Fractional Anisotropy (FA) reduction, indicating a greater disorganization of fibers, and accordingly an increased Orientation Dispersion Index (ODI), which indicates more dispersed fibers. We also highlighted a negative correlation between motor tic severity (quantified by the YGTSS) and neurite density (ND) and free water fraction (FISO).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.