Abstract #5344

The association between adverse childhood experience, PTSD diagnosis and White matter integrity.

Richard Okyere Nkrumah¹, Claudius von Schröder², Traute Demirakca ¹, Christian Schmahl², and Gabriele Ende¹

¹Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Clinic for Psychosomatics and Psychotherapeutic Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Synopsis

Keywords: Psychiatric Disorders, Trauma, Adverse childhood experiences, PTSD, White matter integrityAdverse childhood experiences (ACE) are well-known risk factors for the development of PTSD later in life. The overall effect of ACE on WM integrity and the moderation effect of PTSD in this relation are still being researched. Using a total of 78 participants with any form of ACE, we show that ACE was negatively correlated with WM integrity in the genu and body of the corpus callosum and the bilateral uncinated fasciculus after controlling for overall psychological burden. The overall strength of this effect changed in corpus callosum and uncinated fasciculus when PTSD was added as a moderator variable.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.