Abstract #5346

Differential lesion volume progression following MR-guided focused ultrasound thalamotomy for Essential Tremor

Conrad P Rockel^1,2, Sarah Scott³, Erin L Mazerolle⁴, Samuel Pichardo^1,2, Davide Martino^1,2, Tejas Sankar⁵, Zelma Kiss^1,2,6, and Bruce Pike^1,2

¹Radiology and Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ³University of Calgary, Calgary, AB, Canada, ⁴Dept of Psychology, St Francis Xavier University, Antigonish, NS, Canada, ⁵Dept of Surgery, University of Alberta, Edmonton, AB, Canada, ⁶Dept of Surgery, University of Calgary, Calgary, AB, Canada

Synopsis

Keywords: Neurodegeneration, Focused Ultrasound, Movement disorders; treatmentFollowing MRgFUS thalamotomy for Essential Tremor, it was observed that lesions in some patients re-enlarged after the 3-month timepoint following surgery, based on T1-weighted MRI. After grouping patients as NonEnlargers and Enlargers based on this observation, we did not observe significant between-group differences in clinical measures of tremor beyond the 3-month timepoint. Patient demographic- and MRgFUS-related factors did not differ between groups. However, patients in the NonEnlarger group demonstrated significantly greater tremor severity prior to and in early timepoints following MRgFUS thalamotomy, suggesting that the relationship between tremor severity and longitudinal lesion progression may be worthy of further investigation.

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