Abstract #5349

Blood-brain barrier damage and new-onset refractory status epilepticus: an explorative study using dynamic contrast-enhanced MRI

Huiping Li¹, Xian Liu², Ruihong Wang¹, Aili Lu¹, Zhaohui Ma¹, Shibiao Wu¹, Hongji Lu¹, Yaming Du³, Kan Deng⁴, Lixin Wang¹, and Fang Yuan¹

¹Department of Neurocritical Care, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, ²Department of Imaging, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, ³Hubei University of Chinese Medicine, Wuhan, China, ⁴Philips Healthcare, Guangzhou, China

Synopsis

Keywords: Epilepsy, DSC & DCE Perfusion, new-onset refractory status epilepticus; status epilepticusThis is the first study investigating blood-brain barrier (BBB) dysfunction in new-onset refractory status epilepticus (NORSE) using dynamic contrast-enhanced MRI (DCE-MRI). BBBs of NORSE patients were impaired diffusely, and they had significantly higher BBB permeability in the basal ganglia and thalamus compared to encephalitis patients without status epilepticus (SE). Our preliminary findings demonstrate that BBB dysfunction in the basal ganglia and thalamus plays an important role in the pathophysiology of NORSE.

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