Abstract #5352
A feasibility study of susceptibility source separation via chi-separation in amyotrophic lateral sclerosis patients at 7T
Jiye Kim1, Hyeong-Geol Shin2,3, Sooyeon Ji1, Hwihun Jeong1, Hongjun An1, Cheol-Ho Sohn4,5, Sohyun Han6, Huijin Song7, Ju-Hee Chae8, Seok-Jin Choi9, Jung-Joon Sung9, and Jongho Lee1
1Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, 2Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea, Republic of, 5Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, 6Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, Republic of, 7Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of, 8Department of Neurology, College of Medicine, Jeonbuk National University, Jeonju, Korea, Republic of, 9Department of Neurology, College of Medicine, Seoul National University, Seoul, Korea, Republic of
Synopsis
Keywords: Susceptibility, Susceptibility
The in-vivo imaging of iron and myelin concentrations of the motor cortex in amyotrophic lateral sclerosis (ALS) patients has significance in advancing knowledge about the degeneration progress of the disease. Here, we explored the feasibility of applying 𝜒-separation to ALS patients in-vivo at 7T. When the susceptibility values in hand knobs are examined, ALS patients have higher positive susceptibility values than healthy controls, confirming the histological finding of iron accumulation in ALS.
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