Abstract #5355

Standardized QC procedure for vendor-implemented ADC correction of gradient nonlinearity bias in multi-center clinical trials

Thomas L Chenevert¹, Yuxi Pang¹, Debosmita Biswas², Ramesh Paudyal³, Amaresh Konar³, Jiachao Liang⁴, Lisa J Wilmes⁴, Nastaren Abad⁵, Luca Marinelli⁵, Humera Tariq¹, Ajit Devaraj⁶, Dallas Turley⁷, Johannes M Peeters⁸, Nola M Hylton⁴, David C Newitt⁴, Savannah C Partridge², Amita Shukla-Dave^3,9, and Dariya Malyarenko¹

¹Radiology, University of Michigan Health System, Ann Arbor, MI, United States, ²Radiology, University of Washington, Seattle, WA, United States, ³Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁴Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ⁵GE Research Center, Niskayuna, NY, United States, ⁶Clinical Science, Philips Healthcare, Highland Heights, OH, United States, ⁷Philips Healthcare, Bothell, WA, United States, ⁸Clinical Science, Philips, Best, Netherlands, ⁹Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Synopsis

Keywords: Cancer, Diffusion/other diffusion imaging techniques, ADC measurement accuracy, system gradient nonlinearity correction, multi-center oncology imaging trialsGradient nonlinearity (GNL) induces spatial bias in diffusion b-value that confounds apparent diffusion coefficient (ADC) measurements for anatomy offset from MRI scanner isocenter. For emerging vendor-provided GNL correction (GNC) a standardized quality control (QC) procedure is desired to streamline GNC application for multi-site imaging trials that utilize ADC for tumor monitoring and therapy response assessment. This QC procedure was developed and tested on four MRI scanner systems with vendor-provided on-line ADC GNC for trial-specific phantoms and patient scans for head-and-neck, breast, and myelofibrosis cancers.

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