Abstract #5361

Validation of Intravoxel Incoherent Motion (IVIM) as a surrogate marker of vascular density in a rat model of co-morbidities

Bram Callewaert^1,2, Willy Gsell², Marleen Lox¹, Elizabeth Jones^1,3, and Uwe Himmelreich²

¹Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium, ²Department of Imaging and Pathology, University of Leuven, Leuven, Belgium, ³Department of Cardiology, Maastricht University, Maastricht, Netherlands

Synopsis

Keywords: Vessels, Blood vesselsWe assessed whether Intravoxel Incoherent Motion (IVIM) MRI measurements can detect differences in cerebral vascular density obtained by quantitative immunohistochemistry. In vivo IVIM measurements were correlated with invasive measurements of the microvascular density in a rat model of vascular comorbidities. Our results indicate that IVIM can be used to indirectly measure difference in the vascular density of different brain regions

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