Abstract #5369

Using FW-DTI and VBM to identify white matter microstructural integrity and grey matter density in a preclinical model of Alzheimer’s disease

Maurizio Bergamino¹, Megan R Nelson^1,2, Asfia Numani¹, Matthew L Scarpelli³, Deborah Healey⁴, Alberto Fuentes¹, Gregory Turner¹, and Ashley M Stokes¹

¹Barrow Neurological Institute, Phoenix, AZ, United States, ²Arizona State University, Tempe, AZ, United States, ³Purdue University, West Lafayette, IN, United States, ⁴MD Anderson Cancer center, Houston, TX, United States

Synopsis

Keywords: Data Analysis, Diffusion/other diffusion imaging techniquesThe objective of this study was to assess white matter integrity and grey matter volume density in a mouse model of Alzheimer’s disease (3xTg-AD) using free-water (FW) diffusion tensor imaging (FW-DTI) and voxel-based morphometry (VBM). Additionally, histological analyses of amyloid and tau protein in different regions across the brain were examined.

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