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Abstract #5370

Quantitative analysis of metabolites in mouse optical track after severe traumatic brain injury using magnetic resonance spectroscopy

Roxan Ara1, Fengchong Kong1, Manish Kumar2, Hannah MCMICHAEL2, Mario ESPINOSA PALACIO2, Meenakshi AHLUWALIA2, Krishnan M DHANDAPANI2, Kumar VAIBHAV2,3, and Asamoah Bosomtwi4
1Georgia Cancer Center, Augusta University, Augusta, GA, United States, 2Neurosurgery, Augusta University, Augusta, GA, United States, 3Oral Biology and Diagnostic, Augusta University, Augusta, GA, United States, 4Georgia Cancer Center, Georgia medical College, Augusta, GA, United States

Synopsis

Keywords: Data Acquisition, Metabolism, SpectroscopyTraumatic brain injury (TBI) is associated with an increased risk of cognitive and neurodegenerative complications that may develop and persist years after injury. Altered metabolism is considered to be the earliest possible sign of tissue injury and will be present before any structural changes can be detected. Magnetic resonance spectroscopy is a useful technology for longitudinal assessments, which are critical for understanding altered neurochemical concentrations following TBI, suggesting impaired neurotransmission and energy generation, neuronal injury/death, and oxidative stress

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Keywords