Keywords: Oxygenation, Oxygenation, BOLD, OE-MRI, DCE-MRI, TOLD, QSM, relaxometry, MR oximetry, hypoxia
We will review 1H MR-oximetry techniques including R1, R2*, DCE, and susceptibility-based techniques. We will present the basic principles behind each technique and the results of representative studies that show the relationship between MR-derived markers and blood and tissue oxygenation or hypoxia. We will also discuss oxygen modulation techniques in animal models and humans, report on trends in 1H MR-based oximetry techniques over the last two decades, and summarize the current state and challenges in the field as a whole.
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