Abstract #5436
Antiretroviral therapy use is associated with ectopic pericardial and paracardiac adipose deposition in people living with HIV
Patricia Mazwi Maishi1,2,3, Pheletso Letuka3,4,5, Daniel Mutithu3,4,5, Olukayode Aremu3,4,5, Alladin Speelman6, Stephen Jermy1,2,3, Petronella Samuels1,2,3, Tasnim Bana3,4,5, Mpiko Ntsekhe5, Morne Kahts3,4,5, Jason Baker7, Hadil Saad8, Markella Zanni9, Christopher Longenecker10, and Ntobeko Ntusi2,3,4,5
1Division of Biomedical Engineering,Department of Human Biology, University of Cape Town, Cape Town, South Africa, 2Cape Universities Body Imaging Centre, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, 3South African Medical Research Council Extramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa, 4Cape Heart Institute Department of Medicine, University of Cape Town, Cape Town, South Africa, 5Division of Cardiology Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa, 6Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa, 7Hennepin Healthcare Research Institute and Department of Medicine, University of Minnesota, Minneapolis, MN, United States, 8Charite University and Noninvasive Cardiac Imaging, Klinik und Poliklinik fur Kardiolgie und Nephrologie, Charite University, Berlin, Germany, 9Metabolism Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, United States, 10Division of Cardiology and Department of Global Health, University of Washington, Seattle, WA, United States
Synopsis
Cardiovascular disease (CVD) is a major contributor to morbidity and mortality in people living with human immunodeficiency virus (PLHIV). In the general population, increased pericardiac adipose tissue is associated with poor cardiovascular outcomes, but its role in HIV-associated CVD is not well described. Using cardiovascular magnetic resonance (CMR), we report increased pericardial adipose tissue (PAT) and paracardiac adipose tissue (ParaAT) in PLHIV on ART compared to uninfected controls, with untreated PLHIV having an intermediate phenotype. For PLHIV not on ART, myocardial inflammation is associated with more significant impairment in strain and tissue characteristics, but not PAT and ParaAT volume.
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