Abstract #0003

Cross-Vendor Multiparametric Mapping of the Human Brain Using 3D-QALAS: A Multicenter & Multivendor Study

Shohei Fujita^1,2,3,4, Borjan Gagoski^4,5, Ken-Pin Hwang⁶, Akifumi Hagiwara¹, Marcel Warntjes^7,8, Issei Fukunaga¹, Wataru Uchida¹, Yuya Saito¹, Towa Sekine¹, Rina Tachibana¹, Tomoya Muroi¹, Toshiya Akatsu¹, Akihiro Kasahara², Ryo Sato², Tsuyoshi Ueyama², Christina Andica^1,9, Koji Kamagata¹, Shiori Amemiya², Hidemasa Takao², Yasunobu Hoshino¹⁰, Yuji Tomizawa¹⁰, Kazumasa Yokoyama¹⁰, Berkin Bilgic^3,4,11, Nobutaka Hattori¹⁰, Osamu Abe², and Shigeki Aoki¹

¹Department of Radiology, Juntendo University, Tokyo, Japan, ²Department of Radiology, The University of Tokyo, Tokyo, Japan, ³Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ⁴Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁵Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ⁶Department of Imaging Physics,, MD Anderson Cancer Center, Houston, TX, United States, ⁷SyntheticMR, Linköping, Sweden, ⁸Center for Medical Imaging Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ⁹Faculty of Health Data Science, Juntendo University, Chiba, Japan, ¹⁰Department of Neurology, Juntendo University, Tokyo, Japan, ¹¹Harvard/MIT Health Sciences and Technology, Cambridge, MA, United States

Synopsis

Keywords: YIA, Neuro

Motivation: To address the unmet need for a cross-vendor, multiparametric technique to facilitate data pooling across sites.

Goal(s): To evaluate a vendor-standardized multiparametric mapping scheme based on 3D-QALAS for whole-brain T1, T2, and proton density (PD) mapping.

Approach: Intra-scanner repeatability and inter-vendor reproducibility were evaluated in vivo on five different 3T systems from four vendors (GE, Philips, Siemens, and Canon). Patients with multiple sclerosis were scanned on systems from different vendors to assess the feasibility of the scheme in real-world clinical settings.

Results: 3D-QALAS provided T1, T2, and PD with coefficient of variations <4.0% using 3T scanners from different manufacturers.

Impact: The four major vendors used in this study constitute a considerable portion of the global installation base, demonstrating the value of cross-vendor quantitative technique 3D-QALAS for imaging in clinical sites with multiple vendors, as well as in multicenter research settings.

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