Abstract #0024
Combined DW-MRI and DW-MRS sensitivity to glioma tumour microenvironment: a preliminary study
Marco Palombo1,2, Samuel Rot3,4, Matteo Figini5, Elizabeth Powell6, Bhavana Solanky3,7, Chloe Najac8, Bernard Siow9,10, Jeremy Rees11, Ciaran Hill11, Eleftheria Panagiotaki5, Itamar Ronen12, and Harpreet Hyare13
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 2School of Computer Science, Cardiff University, Cardiff, United Kingdom, 3NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 4Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 5Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 6Centre for Medical Image Computing, Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 7Centre for Medical Image Computing, Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, 8Department of Radiology, C.J. Gorter MRI Center, Leiden University Medical Center, Leiden, Netherlands, 9In Vivo Imaging, The Francis Crick Institute, London, United Kingdom, 10Centre for Medical Image Computing, University College London, London, United Kingdom, 11NMR UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 12Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom, 13NMR Research Unit, Queen Square UCL Queen Square Institute of Neurology, University College London, London, United Kingdom
Synopsis
Keywords: Tumors (Pre-Treatment), Cancer, Microstructure, Diffusion, Spectroscopy
Motivation: Understanding the complexity of the tumour microenvironment is critical for understanding glioma progression and developing effective therapies.
Goal(s): To develop a non-invasive imaging pipeline for characterization of the glioma tumor microenvironment.
Approach: Combining DW-MRI and DW-MRS to enhance the characterization of a spectrum of gliomas as a feasibility study.
Results: Changes in neuronal (tNAA) and glial (tCho) metabolites apparent diffusion coefficients suggest neuronal atrophy and glial activation/reaction in tumor core, respectively. Changes in intracellular and extracellular volume fractions and extracellular diffusivity quantified by DW-MRI support and complement metabolite DW-MRS result and further suggest a more infiltrative marging in IDH mutant tumors.
Impact: Combination DW-MRI and DW-MRS has potential to characterize the glioma microenvironment for improved understanding of radio-resistance and developing more effective therapies.
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