Abstract #0029

Choroid Plexus Area and Permeability in Dementia with Lewy Bodies

Ziming Xu¹, Xize Gao¹, Jinghuan Gan², Zhichao Chen², Yong Ji³, and Huijun Chen¹

¹Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, Beijing, China, ²Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China, Beijing, China, ³Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China, Tianjin, China

Synopsis

Keywords: Other Neurodegeneration, DSC & DCE Perfusion, choroid plexus; dementia with Lewy bodies

Motivation: The choroid plexus has been demonstrated to play a significant role in the pathophysiology of dementia with Lewy bodies (DLB), however the imaging characteristics are not yet explored.

Goal(s): Our goal was to assess choroid plexus area and permeability based on MRI in DLB patients.

Approach: DLB patients were imaged to acquire choroid plexus area and permeability and compared with patients with Alzheimer’s disease and healthy controls.

Results: DLB patients exhibited larger area and lower fractional plasma volume in choroid plexus than healthy controls. Additionally, they were found to be significantly associated with the mini-mental state examination score.

Impact: The larger choroid plexus area and lower fractional plasma volume detected by T1-weighted MRI and DCE-MRI in dementia with Lewy bodies provide a non-invasive and quantitative metric for advancing the diagnosis and treatment of dementia with Lewy bodies.

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