Abstract #0032

Unveiling Choroid Plexus Changes in Multiple Sclerosis using 7T MRI

Zhe Sun^1,2,3 and Yulin Ge^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, NYU Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU Grossman School of Medicine, New York, NY, United States, ³Vilcek Institute of Graduate Biomedical Sciences, NYU Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, choroid plexus, neurodegeneration, neuroinflammation

Motivation: Conventional imaging limits the assessment of choroid plexus (ChP) inflammatory activity in multiple sclerosis (MS).

Goal(s): Use high-resolution MRI with 0.25mm² matrix at 7T to assess ChP changes in MS patients compared to controls and explore correlations with lesion volumes.

Approach: In 14 MS patients and 9 controls, ChPs were categorized into vascular and stromal compartments using 7T T2* imaging, and vessel-to-stroma ration was compared between the two groups.

Results: The ChP's vessel-to-stroma ratio quantified by 7T T2*w MRI was lower in MS patients, correlating negatively with lesion volume. Furthermore, the age-related decline was more rapid in MS patients compared to controls.

Impact: This pilot study suggests that the vessel-to-stroma ratio of ChP, as revealed by high-resolution 2D-GRE 7T T2* imaging, could potentially serve as an imaging marker for inflammatory and degenerative changes of ChP in MS patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.