Abstract #0036

Fast imaging of intravenous Gadolinium-based contrast agents entrance into ventricular CSF via choroid plexus in healthy subjects

Yuanqi Sun^1,2,3, Di Cao^1,2,3, Yinghao Li^1,2,3, Jay J. Pillai^4,5, Adrian Paez¹, Jacob M. Pogson⁶, Linda Knutsson^1,7, Peter B. Barker^1,2, Peter C.M. Van Zijl^1,2,3, Arnold Bakker^7,8, Bryan K Ward⁶, and Jun Hua^1,2

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ²Neurosection, Division of MRI Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁴Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Division of Neuroradiology, Mayo Clinic College of Medicine and Science, Rochester, MN, United States, ⁶Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁸Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Neurofluids, DSC & DCE Perfusion, lymphatic; CSF; ISF; GBCA

Motivation: Intravenously administered gadolinium-based-contrast-agents (GBCAs) can enter the lateral-ventricle (LV) via choroid-plexus (CP). However, systematic investigation of GBCA accumulation in ventricular CSF via CP in healthy subjects is limited.

Goal(s): To measure GBCA-induced signal changes in the LV and CSF around CP immediately and 4 hours after intravenous GBCA administration.

Approach: Dynamic-susceptibility-contrast-in-the-CSF (cDSC) MRI was performed in 25 healthy subjects.

Results: At ~20s post-GBCA, GBCA-induced signal changes were detected in the CSF around CP but not in the rest of LV. After 4 hours, GBCA-induced signal changes also became significant in the entire LV. GBCA-amount in the LV showed an age correlation.

Impact: These results provided direct imaging evidence that intravenous GBCA can pass the BCSFB in the CP and enter ventricular CSF in healthy subjects.

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