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Abstract #0039

Time-Resolved Biomechanics using Spectro-Dynamic MRI: Proof of Principle in the Muscles of the Thigh

Max H.C. van Riel1, David G.J. Heesterbeek1, Martijn Froeling1, Tristan van Leeuwen2, Cornelis A.T. van den Berg1, and Alessandro Sbrizzi1
1Department of Radiotherapy, Computational Imaging Group for MR Diagnostics and Therapy, UMC Utrecht, Utrecht, Netherlands, 2Mathematical Institute, Utrecht University, Utrecht, Netherlands

Synopsis

Keywords: Image Reconstruction, Muscle, Time-Resolved, Motion, Strain

Motivation: Measurements of biomechanical tissue properties require time-resolved reconstructions from dynamic experiments. The Spectro-Dynamic MRI framework achieves this by working directly from k-space data.

Goal(s): To develop an experimental setup and reconstruction method with which time-resolved biomechanical information can be measured in vivo.

Approach: An inflatable pressure cuff deformed the thigh muscles of a volunteer. Time-resolved images and strain maps were reconstructed directly from k-space data using the Spectro-Dynamic MRI framework.

Results: Principal strains were obtained for different muscles in the thigh at a temporal resolution of 352 ms. The first principal strain direction could differentiate between muscle structures, indicating different underlying biomechanical properties.

Impact: The reconstruction of time-resolved images and strains using Spectro-Dynamic MRI allows for time-resolved measurements of biomechanical parameters during dynamic loads with a straightforward experimental setup. This information is useful for studying the mechanical behavior of tissues.

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Keywords