Keywords: Biomarkers, Hyperpolarized MR (Non-Gas)
Motivation: Long-lasting brain issues including cognitive impairments after infections have become a worldwide problem after COVID-19.
Goal(s): Our goal was to detect brain metabolic alteration at a late phase of immune fatigue.
Approach: Parahydrogen-polarized 13C MRI of pyruvate metabolism was applied in the brain of 3 days poly I:C treated mice.
Results: Alteration of brain pyruvate metabolism toward glycolysis was observed in both acute phase at day 3 and late phase at day 14 of immune fatigue model mice, which was correlated with diminished dopamine signal marker and nighttime moving distance in open-field test.
Impact: Our demonstration of a detectable alteration of brain pyruvate metabolism by parahydrogen-polarized 13C MRI at a late phase of immune fatigue mice can be a useful biomarker of cognitive impairments after infections such as brain fog of long-COVID.
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