Abstract #0056

Atlas-based Analysis and Deformation-Based Morphometry of Structural MRI to Study Effects of Hypertension on Rat Brain Structure

Haley Elizabeth Wiskoski^1,2, Loi Do¹, Marc Zempare³, Natalie Carey³, Amy Delmendray³, Kimberly Young³, Kimberly Bohne³, Monica Chawla³, Pradyumna Bharadwaj⁴, Kenneth Mitchell⁵, Gene Alexander^3,4,6, Carol Barnes^3,4, and Theodore Trouard^1,3,7

¹Department of Biomedical Engineering, The University of Arizona, Tucson, AZ, United States, ²James C. Wyant College of Optical Sciences, The University of Arizona, Tucson, AZ, United States, ³Evelyn F. McKnight Brain Institute, The University of Arizona, Tucson, AZ, United States, ⁴Department of Psychology, Neurology, and Neuroscience, The University of Arizona, Tucson, AZ, United States, ⁵Health Sciences Center, Tulane University, New Orleans, LA, United States, ⁶Division of Neural Systems, Memory, and Aging, The University of Arizona, Tucson, AZ, United States, ⁷Department of Medical Imaging, The University of Arizona, Tucson, AZ, United States

Synopsis

Keywords: Preclinical Image Analysis, Hypertension

Motivation: Hypertension (HTN) is a known risk factor for cardiovascular disease and cognitive decline, with a need to understand its effects on brain function and structure using animal models.

Goal(s): We aim to investigate impact of HTN on the brain of transgenic Cyp1a1-Ren2 rats through atlas-based and deformation-based analysis of high-resolution structural MRI.

Approach: Rats were divided into control and hypertensive groups. Structural MRI was carried out, upon which atlas-based analysis and deformation-based morphometry were performed.

Results: Induced HTN significantly affected peripheral organs but showed no significant brain volume changes or cognitive differences. This suggests potential brain protection mechanisms against HTN, warranting further investigation.

Impact: This research explores effects of hypertension on the brain using a rat model and structural MRI. Results show the brain appears resilient to induced hypertension compared to peripheral organs, highlighting need for investigation into protective mechanisms and their potential degradation.

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