Abstract #0057

Regional ventilation measured by 3D phase-resolved functional lung MRI improves after dual bronchodilator treatment in patients with COPD

Filip Klimeš^1,2, Andreas Voskrebenzev^1,2, Marcel Gutberlet^1,2, Till Frederik Kaireit^1,2, Robert Grimm³, Frank Wacker^1,2, Jens Hohlfeld^4,5, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³MR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany, ⁴Department of Clinical Airway Research, Franhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, ⁵Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany

Synopsis

Keywords: Lung, Lung, COPD, Dual bronchodilator, treatment

Motivation: Bronchodilators relieve the symptoms of respiratory conditions, such as chronic obstructive lung disease (COPD). 3D PREFUL MRI offers a non-invasive assessment of pulmonary ventilation. It is unclear whether 3D PREFUL parameters are sensitive to ventilation changes induced by bronchodilators.

Goal(s): To determine whether 3D PREFUL parameters enable to measure response to dual bronchodilator therapy in COPD.

Approach: 3D PREFUL MRI and spirometry at baseline and 2 weeks after initiation of therapy.

Results: Ventilation assessed by 3D PREFUL parameters significantly improved by bronchodilator therapy. Relative changes of 3D PREFUL ventilation defect percentage parameters were similar to relative change differences of FEV1.

Impact: 3D PREFUL MRI derived ventilation maps show significantly reduced ventilation defects in COPD patients after bronchodilator therapy. This positions 3D PREFUL MRI as a promising candidate for non-invasive monitoring of regional ventilation changes in future clinical studies.

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