Abstract #0061

Simultaneous extraction of Oxygen enhanced MRI indices and α-mapping in Cystic Fibrosis

Marta Tibiletti¹, Christopher Short^2,3, Jo Naish^1,4, John Charles Waterton^1,5, Mary Abkir^2,3, Thomas Semple^2,6, Simon Padley^2,3, Jane C Davies^2,3, and Geoff JM Parker^1,7

¹Bioxydyn Ltd, Manchester, United Kingdom, ²National Heart & Lung Institute, Imperial College London, London, United Kingdom, ³Royal Brompton Hospital, Guy's & St Thomas’ Trust, London, United Kingdom, ⁴MCMR, Manchester University NHS Foundation Trust, Manchester, United Kingdom, ⁵Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom, ⁶Centre for Paediatric and Child Health, Imperial College London, London, United Kingdom, ⁷Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom

Synopsis

Keywords: Lung, Oxygenation

Motivation: Functional lung MRI methods based on different physical principles are available, but their relationship is not well understood in disease

Goal(s): Compare dynamic oxygen-enhanced MRI and ‘α-mapping’ extracted from the same acquisition with lung clearance index (LCI) in a cystic fibrosis (CF) population

Approach: Oxygen enhancement at 30s to 60s after oxygen start and at plateau are compared with α-mapping in 45 CF patients.

Results: α-mapping and OE-MRI correlate strongly with LCI, confirming their validity. Dynamic OE-MRI identifies areas of fast and slow enhancement, which may be areas of collateral ventilation. α-mapping cannot separate non-ventilated areas from areas of slow gas arrival.

Impact: Dynamic OE-MRI and α-mapping are extracted from a single acquisition and compared in a cystic fibrosis population. Dynamic OE-MRI identifies areas of fast and slow enhancement, possible collateral ventilation. α-Index cannot separate non-ventilated areas from areas of slow gas arrival.

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