Abstract #0069

Reduced coupling between cerebrospinal fluid flow and global brain activity in post-stroke dementia with subcortical lesion

Nan Zhang¹, Huaying Cai², Linhui Ni², Guocan Han³, Dan Wu¹, Zhiyong Zhao¹, and Zixuan Lin¹

¹Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, ²Department of Neurology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China, ³Department of Radiology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Stroke, Dementia, Neurovascular，glymphatic system

Motivation: Post-stroke dementia (PSD) affects up to one third of stroke survivors but the underlying mechanism remains unclear.

Goal(s): We hypothesized that dysfunction in glymphatic system may play a role in the pathogenesis in PSD and aim to investigate it with non-contrast imaging method.

Approach: Coupling between BOLD and cerebrospinal fluid (CSF) signal was compared between PSD, post-stroke non-dementia (PSND) and normal controls.

Results: Significant reduction in the BOLD-CSF coupling was found in PSD patients, which is negatively associated with cognitive test scores.

Impact: The present work revealed a reduced BOLD-CSF coupling in PSD patients, indicating a potential abnormality in the glymphatic function.

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