Keywords: Stroke, Stroke
Motivation: Determine which chronic post-stroke patients with hand motor deficits will benefit from cerebellar deep brain stimulation (DBS).
Goal(s): Test the hypothesis that patients with metabolic injury to fewer rsfMRI networks experienced greater motor improvement after DBS.
Approach: Analysis of baseline 18F-fluorodeoxyglucose PET identified the most metabolically injured brain region (“PET-max-imbalance-region”) for 12 patients. The total number of rsfMRI networks and volume of functionally connected brain associated with the “PET-max-imbalance-region” were calculated.
Results: : Lower numbers of rsfMRI networks intersecting the “PET-max-imbalance-region” and total volumes of brain contained within networks and functionally connected to the “PET-max-imbalance-region” were associated with greater arm function improvement after DBS.
Impact: Metrics quantifying the extent of resting-state functional MRI networks associated with the most metabolically injured brain region could be considered as inclusion/exclusion criteria when evaluating candidates for cerebellar deep brain stimulation treatment for chronic post-stroke hand motor deficits.
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