Keywords: Stroke, Stroke, ischemic penumbra，wake-up stroke，Amido-proton transfer，Arterial spin labeling，Diffusion weighted imaging
Motivation: Ischemic Penumbra (IP) is an Ischemic tissue that is "basically reversible” during effective treatment. amide proton transfer-weighted (APT) imaging based on the PH value of biological tissues may have certain application value in evaluating the range of ischemic penumbra
Goal(s): This study aimed to explore if APTw imaging has the clinical potential to predict Ischemic Penumbra
Approach: This study intends to apply APTw imaging technology to wake-up stroke patients to explore whether this technology can more accurately evaluate the range of IP compared with ASL technology
Results: The APTw-DWI mismatch model has the potential to evaluate the ischemic penumbra in wake-up stroke patients
Impact: APTw combined with DWI provides a new method to distinguish ischemic penumbra in patients with wake-up stroke accurately.
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