Keywords: Stroke, Stroke, Cerebrovascular Reactivity, Moyamoya
Motivation: Moyamoya impairment is commonly assessed by anatomical MRI and angiography, yet these methods lack information on compensatory parenchymal behaviors.
Goal(s): To evaluate whether cerebrovascular compliance measures reflect recent ischemic symptomology and may have relevance as biomarkers of stroke risk or as endpoints in interventional trials.
Approach: We applied logistic regression analysis in 73 moyamoya participants to evaluate whether BOLD hypercapnia-induced reactivity or reactivity delays related to recent ischemic symptoms.
Results: Reactivity delays in the flow territory of ischemic symptoms were found to be significantly lengthened compared to the asymptomatic territories. Maximum vasodilatory responses were less closely associated with symptoms.
Impact: The sensitivity of the cerebrovascular reactivity timing profiles to recent ischemic symptomology suggests that the dynamics of vascular compliance may have clinical relevance as a diagnostic measurement of impairment or treatment response in moyamoya.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords