Abstract #0121

In vivo tensor-valued diffusion MRI evaluates isotropic and anisotropic kurtosis mismatch in a middle cerebral artery occlusion stroke model

Mingyao Liang^1,2, Jiangyu Yuang^1,2, Tingting Gu³, Yaohui Tang³, and Yi He^1,2

¹the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China, ²Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China, ³Department of Biomedical Engineering, Shanghai jiaotong university, Shanghai, China

Synopsis

Keywords: Microstructure, Ischemia, MKI MKA mismatch isotropic kurtosis anisotropic kurtosis

Motivation: Diffusion-weighted imaging (DWI) is widely used in the early detection of stroke, providing valuable information on the infarct core and ischemic penumbra. The mismatch between DWI and more advanced dMRI enhances the accuracy of stroke lesion characterization.

Goal(s): Our goal is to explore whether advanced tensor-valued diffusion MRI (dMRI) can yield sensitive microstructural readouts and evaluate the mismatch between anisotropic and isotropic kurtosis as a potential biomarker for stroke.

Approach: We performed tensor-valued dMRI in a middle cerebral artery occlusion (MCAO) rodent model.

Results: The tensor-valued diffusion MRI demonstrated significant mean diffusivity, mean kurtosis, anisotropic kurtosis, and isotropic kurtosis lesion mismatch.

Impact: Tensor-valued diffusion MRI reveals the isotropic and anisotropic in kurtosis/diffusion lesion mismatch in an animal model of acute stroke, the tensor-valued dMRI may help characterize different microstructural features of acute stroke lesions for precision medicine.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.