Keywords: Microstructure, Diffusion/other diffusion imaging techniques
Motivation: Addressing the unmet need for non-invasive non-alcoholic steatohepatitis (NASH) diagnosis.
Goal(s): Assessing MRI cytometry’s potential for quantifying alterations in cell sizes and cell densities linked to inflammation, a critical factor in NASH diagnosis.
Approach: Histology-based simulations were used to assess MRI cytometry's performance across various SNR levels in normal and NASH liver tissues. Additionally, used MRI cytometry to distinguish healthy liver from NASH with a clinical 3T scanner.
Results: Both simulations and in vivo data revealed increased cell density and reduced cell sizes in inflammatory areas compared to steatosis and healthy liver tissues.
Impact: Findings of this study establish a strong foundation for future investigations into the role of non-invasive assessment of liver cellular characteristics in diagnosing NASH, with the ultimate goal of reducing the necessity for liver biopsy.
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