Abstract #0146

Hybrid Multi-Echo Radial Look-Locker (hME-rLL) Acquisition for Joint Estimation of water-T1, PDFF, and R2*

Eze Ahanonu¹, Ute Goerke², Brian Toner³, Kevin Johnson⁴, Vibhas Deshpande⁵, Shu-Fu Shih⁶, Xiaodong Zhong⁶, Holden Wu⁶, Ali Bilgin^1,7, and Maria Altbach⁸

¹Electrical and Computer Engineering, University of Arizona, Tucson, AZ, United States, ²Siemens Healthineers, Tucson, AZ, United States, ³Applied Mathematics, University of Arizona, Tucson, AZ, United States, ⁴Department of Medical Imaging, University of Arizona, Tucson, AZ, United States, ⁵Siemens Healthineers, Austin, TX, United States, ⁶Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ⁷Biomedical Engineering, University of Arizona, Tucson, AZ, United States, ⁸Medical Imaging, University of Arizona, Tucson, AZ, United States

Synopsis

Keywords: Quantitative Imaging, Liver, T1 mapping, R2* mapping, PDFF mapping

Motivation: Reducing the time required to achieve comprehensive liver evaluation will improve scanning efficiency and increase access to non-invasive diagnostic tools

Goal(s): To develop an acquisition protocol which allows accurate estimation of water-only T1 ($$$T1w$$$), PDFF, and R2*

Approach: Combing dual-echo and extended-echo (>2) readout into a single acquisition, using the extended-echo acquisition to estimate the field-map, R2*, and PDFF. Then using the R2* and field maps to perform fat/water decomposition on the dual-echo acquisition for $$$T1w$$$ estimation.

Results: Both phantom and in vivo results demonstrated that $$$T1w$$$, R2*, and PDFF can be accurately estimated using the proposed approach.

Impact: Increasing the efficiency of MRI sequence and protocols allows for reduced scan time and improved scanner efficiency. These contributions make the diagnostic process easier for patients and physicians, which should result in improved healthcare.

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